How should this medicine be used? Didanosine comes as capsules that can be chewed or mixed with water, long-acting capsules, a solution (liquid), and a powder to be mixed with water. All are taken by mouth. Generic Videx (Didanosine) is usually taken once or twice daily on an empty stomach, either 2 hours after food or 30 minutes before. Follow the directions on your prescription label carefully, and ask your doctor to explain any part you don't understand. Take Generic Videx (Didanosine) exactly as directed. Do not take more or less than prescribed by your doctor.

If you are using the long-acting capsules( extended-release) capsules, swallow them whole; do not chew, split, or crush.

If you are using the capsules, do not swallow them whole. Chew the capsules well or mix them in at least one ounce (2 tablespoonfuls) of water and stir well to dissolve the capsules before swallowing. You may add one ounce (2 tablespoonfuls) of clear apple juice to the mixture for flavor, if needed. Do not use any other kind of juice. Drink all of the liquid right away.

If you are using the powder, you must mix it with water immediately before you take it. Pour the powder into a glass with 4 ounces of water. Stir the mixture for 2 or 3 minutes until the powder is completely dissolved. Drink all of the liquid right away. Do not mix the powder with fruit juice or any other liquid.

If you are using the solution, you should shake it well before each use to mix the medication evenly.

What side effects can this medication cause? The side effects include:

diarrhea headache muscle pain Tell your doctor if any of these symptoms are severe or do not go away.

The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

hives skin rash chill